When Searches Become Futile

When will resistance be futile?

Cancer cells rapidly evolve a multitude of defense mechanisms to evade the effects of the oncologist's drug arsenal. Unfortunately, clinical strategies to overcome these lag far behind. This mismatch likely underlies our inability to implement new durable treatment strategies. Here, a new form of multidrug resistance, inducible drug glucuronidation, is discussed. This form was discovered while ...

When Agents Become Principals:

This paper argues that the publishing of academic research by and large belongs to the public sector domain, and that the scientific knowledge stemming from the public sectors is important for innovation. In 2004 the Norwegian Association of Higher Education Institutions (UHR) introduced an incentive based system in which academic institutions receive economic compensation as a function or thei...

When does conscientiousness become perfectionism ?

Gordon L. Flett, PhD Canada Research Chair in Personality and Health York University Toronto Mr. C is a 50-year-old professional writer who recently made a serious suicide attempt. At his initial session, Mr. C was hesitant to discuss his situation and reason for attending. He did, however, bring a copy of his résumé so the therapist could “get to know him quickly.” He said he had been depresse...

When Does Influence Become Undue?

When cells become organelle donors.

More than 40 variations of intercellular organelle transfer, such as a mitochondria or lysosome originating in one cell being transported to another cell, have been described. We review the mechanisms and subcellular structures by which, and conditions under which, transfer occurs, with particular attention paid to the role of external cell stress in activating transfer. We propose a research a...